Source comparison
MOTS-c Fat Loss Protocol Dosage Timing: Weekly Structure Comparison
Pre-Workout Only 3–4x/week 30–60 min before resistance or HIIT +18–22% +10–12% Maximizes AMPK activation and mitochondrial signaling. The gold standard for body recomposition research Mixed (Pre-Workout + Rest Days) 5x/week 2–3 pre-workout, 2 rest days (mornin
This comparison does not assign a generated winner or score.
- Pre-Workout Only
- 3–4x/week
- 30–60 min before resistance or HIIT
- +18–22%
- +10–12%
- Maximizes AMPK activation and mitochondrial signaling. The gold standard for body recomposition research
- Mixed (Pre-Workout + Rest Days)
- 5x/week
- 2–3 pre-workout, 2 rest days (morning fasted)
- +14–17%
- +6–8%
- Moderate improvement. Rest-day doses contribute modestly but dilute per-dose efficacy
- Rest Day Only
- 3x/week
- Morning fasted, no exercise within 6 hours
- +8–11%
- +2–4%
- Minimal body composition benefit. Insulin sensitivity improves but mitochondrial adaptation is negligible
- Evening (Pre-Sleep)
- 1–2 hours before bed, no exercise
- +5–8%
- 0–2%
- Least effective timing. Circulating peptide peaks during sleep when AMPK activity is lowest