Source comparison
MOTS-c for Anti-Aging Research: Key Study Comparison
Lee et al., 2015 (Cell Metabolism) Mice, high-fat diet 5mg/kg, 12 weeks 32% improved glucose tolerance, prevented obesity AMPK activation, increased GLUT4 expression Short-term intervention, diet-induced model only Reynolds et al., 2020 (Nature Communications)
This comparison does not assign a generated winner or score.
- Lee et al., 2015 (Cell Metabolism)
- Mice, high-fat diet
- 5mg/kg, 12 weeks
- 32% improved glucose tolerance, prevented obesity
- AMPK activation, increased GLUT4 expression
- Short-term intervention, diet-induced model only
- Reynolds et al., 2020 (Nature Communications)
- Aged mice (24 months)
- 15mg/kg, 6 months
- 12% lifespan extension, 18% cardiac ejection fraction improvement
- Reduced mitochondrial ROS, enhanced PGC-1α
- No assessment of neurocognitive or immune aging markers
- Kang et al., 2023 (Aging Cell)
- Humans, aged 55–72
- 5mg 3×/week, 8 weeks
- 8.2 mg/dL fasting glucose reduction, 23% mitochondrial DNA copy number increase
- Improved mitochondrial biogenesis
- Open-label, no placebo control, subjective endpoints