Source comparison
MOTS-C for Endurance Athletes: Performance Metric Comparison
VO2max Improvement +6–8% over 8 weeks +12–15% over 8 weeks Increased mitochondrial density and cristae surface area Significant. Doubles aerobic capacity gains with identical training volume Lactate Threshold Shift +3–5% of VO2max +8–12% of VO2max Improved pyr
This comparison does not assign a generated winner or score.
- VO2max Improvement
- +6–8% over 8 weeks
- +12–15% over 8 weeks
- Increased mitochondrial density and cristae surface area
- Significant. Doubles aerobic capacity gains with identical training volume
- Lactate Threshold Shift
- +3–5% of VO2max
- +8–12% of VO2max
- Improved pyruvate oxidation efficiency, delayed lactate accumulation
- Critical for race-pace sustainability. Allows higher intensity at lower perceived exertion
- Time to Exhaustion at 90% VO2max
- Baseline reference
- +20–24% increase
- Enhanced ATP production rate through mitochondrial respiration
- Substantial. Translates directly to closing speed in competitive scenarios
- Post-Exercise Glycogen Resynthesis
- 5–7% per hour (standard rate)
- 8–10% per hour (accelerated)
- AMPK-mediated GLUT4 translocation independent of insulin
- Moderate but valuable. Shortens recovery windows between high-volume sessions
- Mitochondrial Biogenesis Markers
- +20–30% (PGC-1α, citrate synthase)
- +50–70% (enzyme activity assays)
- Direct AMPK activation triggering mitochondrial gene transcription
- Foundational. Structural adaptations that persist beyond supplementation period