Source comparison
MOTS-C for Marathon Runners: Performance Comparison
Lactate Threshold Pace Improved 6–10 sec/mile at 4 mmol/L Baseline improvement 2–4 sec/mile AMPK-mediated lactate transporter upregulation Clinically significant for sub-3:00 marathon efforts FATmax % VO2max Sustained fat oxidation to 72–75% VO2max Plateau at
This comparison does not assign a generated winner or score.
- Lactate Threshold Pace
- Improved 6–10 sec/mile at 4 mmol/L
- Baseline improvement 2–4 sec/mile
- AMPK-mediated lactate transporter upregulation
- Clinically significant for sub-3:00 marathon efforts
- FATmax % VO2max
- Sustained fat oxidation to 72–75% VO2max
- Plateau at 60–65% VO2max
- Enhanced CPT-1 expression increasing mitochondrial fat transport
- Directly delays glycogen depletion in final race miles
- Mitochondrial Density
- 18–24% increase (muscle biopsy data)
- 8–12% increase over same period
- PGC-1α upregulation independent of training volume
- Adaptation typically requires 12+ months of high-volume training
- Time to VO2max
- Delayed by 45–60 seconds at race pace
- Baseline
- Improved oxidative enzyme activity and oxygen extraction
- Measurable in 10K–half marathon time trial performance
- Glycogen Utilisation
- 15–20% reduction at marathon pace
- Metabolic shift toward fatty acid oxidation
- Translates to sustained pace through mile 22–26