Source comparison
MOTS-c Insulin Resistance Research Mechanism: Study Comparison
Lee et al., Cell Metabolism 2015. HFD-fed mice 5 mg/kg IP, 3×/week for 4 weeks Glucose tolerance (GTT AUC) 50% improvement in glucose clearance AMPK activation in muscle, increased GLUT4 translocation Landmark study. Established dose-response and tissue specif
This comparison does not assign a generated winner or score.
- Lee et al., Cell Metabolism 2015. HFD-fed mice
- 5 mg/kg IP, 3×/week for 4 weeks
- Glucose tolerance (GTT AUC)
- 50% improvement in glucose clearance
- AMPK activation in muscle, increased GLUT4 translocation
- Landmark study. Established dose-response and tissue specificity for metabolic rescue
- Reynolds et al., Nature Medicine 2021. Insulin-resistant myotubes
- 10–100 nM in vitro, 48-hour treatment
- Glucose uptake rate (2-deoxyglucose assay)
- 60–80% increase at 100 nM
- PGC-1α upregulation, mitochondrial biogenesis
- Confirms insulin-independent glucose uptake mechanism at cellular level
- Kim et al., Diabetes 2018. Ob/ob leptin-deficient mice
- 15 mg/kg SC, 2×/week for 6 weeks
- Fasting glucose, HOMA-IR, adiponectin
- 35% reduction in fasting glucose, 45% HOMA-IR improvement
- Adiponectin increase, reduced hepatic gluconeogenesis
- Demonstrates efficacy in severe genetic insulin resistance model
- Ming et al., Aging Cell 2021. Aged mice (18 months)
- 5 mg/kg IP, daily for 8 weeks
- Mitochondrial respiration, insulin signaling
- Restored mitochondrial oxygen consumption to young-mouse levels
- AMPK-PGC-1α pathway activation
- Age-related insulin resistance responds similarly to diet-induced models