Source comparison
MOTS-c Insulin Resistance Research: Study Comparison
Lee et al., Cell Metabolism (2015) Diet-induced obese mice 5 mg/kg daily (IP) Restored insulin sensitivity 30–40% improvement in glucose AUC AMPK activation, GLUT4 translocation First demonstration of insulin-independent glucose disposal via mitochondrial pept
This comparison does not assign a generated winner or score.
- Lee et al., Cell Metabolism (2015)
- Diet-induced obese mice
- 5 mg/kg daily (IP)
- Restored insulin sensitivity
- 30–40% improvement in glucose AUC
- AMPK activation, GLUT4 translocation
- First demonstration of insulin-independent glucose disposal via mitochondrial peptide
- Kim et al., Diabetes (2016)
- High-fat diet mice
- 5 mg/kg 3×/week (IP)
- Reduced adipose inflammation
- 28% reduction in fasting glucose
- TNF-α and IL-6 suppression, NF-κB inhibition
- Anti-inflammatory effects compound direct metabolic action
- Reynolds et al., Nature Communications (2017)
- Aged mice (22 months)
- 15 mg/kg daily (IP)
- Improved exercise capacity
- 18% increase in VO2 max
- PGC-1α upregulation, mitochondrial biogenesis
- Functional outcomes extend beyond glucose metabolism alone
- D'Souza et al., Aging Cell (2020)
- Human primary myotubes (in vitro)
- 1 μM in culture media
- Enhanced insulin signaling
- 42% increase in insulin-stimulated glucose uptake
- Nuclear translocation under oxidative stress
- Human tissue confirms rodent mechanisms translate