Source comparison
MOTS-c Protocol Comparison: Dosing Strategies and Expected Outcomes
Conservative 5–7.5mg 2x/week Pre-fasted cardio 6–8% body fat reduction Best for first-time peptide users; minimises hypoglycemia risk while establishing metabolic adaptation Standard 7.5–10mg 3x/week Pre-training (fasted or fed) 8–12% body fat reduction Optima
This comparison does not assign a generated winner or score.
- Conservative
- 5–7.5mg
- 2x/week
- Pre-fasted cardio
- 6–8% body fat reduction
- Best for first-time peptide users; minimises hypoglycemia risk while establishing metabolic adaptation
- Standard
- 7.5–10mg
- 3x/week
- Pre-training (fasted or fed)
- 8–12% body fat reduction
- Optimal balance between efficacy and tolerability; most clinical data supports this range
- Aggressive
- 10–15mg
- 3–4x/week
- Pre-fasted training + evening dose
- 10–14% body fat reduction
- Higher risk of receptor desensitisation; requires strict dietary adherence and glycogen monitoring
- Maintenance
- 3–5mg
- 1–2x/week
- Flexible
- Prevents fat regain post-protocol
- Used after 12-week intensive phase to sustain AMPK sensitivity without continuous high-dose exposure