Source comparison
MOTS-c Protocol: Research Dose Comparison
USC Cell Metabolism (2015) 5mg (0.5mg/kg in mice) 3x weekly Subcutaneous 30% reduction in fasting glucose, improved OGTT Gold-standard preclinical evidence. Dose-dependent AMPK activation confirmed via Western blot High-Fat Diet Prevention Model 10mg weekly On
This comparison does not assign a generated winner or score.
- USC Cell Metabolism (2015)
- 5mg (0.5mg/kg in mice)
- 3x weekly
- Subcutaneous
- 30% reduction in fasting glucose, improved OGTT
- Gold-standard preclinical evidence. Dose-dependent AMPK activation confirmed via Western blot
- High-Fat Diet Prevention Model
- 10mg weekly
- Once weekly
- Prevented diet-induced insulin resistance over 12 weeks
- Single-dose weekly protocol showed comparable efficacy to split-dose. Simplifies administration
- Aged Rodent Restoration Model
- 15mg weekly
- Restored insulin sensitivity to young-control levels in 8 weeks
- Highest dose tier used in published research. May represent ceiling dose before diminishing returns
- Standard Research Protocol
- 5–10mg weekly
- Once or split 2–3x weekly
- Variable. Timing relative to feeding cycles significantly impacts AMPK response
- Most practical starting point for new protocols. Allows dose titration based on glucose response