Source comparison
MOTS-C Purity: Research-Grade vs Pharmaceutical-Grade Standards
HPLC Purity 98.0–99.5% ≥99.0% MOTS-C at 98% contains ~2% deletion sequences that compete for receptor binding without activating AMPK Endotoxin Level <10 EU/mg <1 EU/mg In vivo studies require low endotoxin to avoid confounding inflammatory responses Sterility
This comparison does not assign a generated winner or score.
- HPLC Purity
- 98.0–99.5%
- ≥99.0%
- MOTS-C at 98% contains ~2% deletion sequences that compete for receptor binding without activating AMPK
- Endotoxin Level
- <10 EU/mg
- <1 EU/mg
- In vivo studies require low endotoxin to avoid confounding inflammatory responses
- Sterility Testing
- Not required
- USP sterility test required
- Critical for any protocol involving injection or cell culture
- Heavy Metals
- Not specified
- <10 ppm lead, <5 ppm arsenic
- Trace metal contamination affects mitochondrial assays directly
- Peptide Content
- 75–90% by weight
- ≥95% by weight
- A '5mg' vial at 75% content delivers only 3.75mg MOTS-C
- Bottom Line
- Sufficient for cell culture and mechanistic studies; unsuitable for human or animal models without additional verification
- Required for any clinical or regulatory submission; cost premium justified only when data must meet FDA or EMA standards