Source comparison
MOTS-C Storage Protocol: Pre-Reconstitution vs Post-Reconstitution
The temperature requirements for MOTS-C change completely once you add solvent. Pre-reconstitution storage keeps the lyophilized powder at −20°C in a standard laboratory or medical-grade freezer. Household freezers typically run colder than −18°C, which is ade
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- The temperature requirements for MOTS-C change completely once you add solvent. Pre-reconstitution storage keeps the lyophilized powder at −20°C in a standard laboratory or medical-grade freezer. Household freezers typically run colder than −18°C, which is adequate, but consistency matters more than absolute temperature. Avoid units with auto-defrost cycles that cause temperature swings. Store the sealed vial upright in a dedicated peptide storage box to prevent condensation from forming on the stopper during freeze-thaw events.
- Once you reconstitute MOTS-C with bacteriostatic water (the standard solvent for research peptides), the storage requirements shift entirely. The reconstituted solution must be refrigerated at 2–8°C immediately after mixing and kept at that temperature continuously. A pharmaceutical-grade refrigerator with digital temperature monitoring is ideal, but a standard household refrigerator set to 4°C works if you verify the internal temperature with a calibrated thermometer. Do not store reconstituted MOTS-C in the door compartment. Temperature fluctuations during door opening can push the vial outside the safe range repeatedly over a 28-day period.
- The 28-day post-reconstitution timeline isn't a safety expiration date like food products. It's the window during which the peptide maintains research-grade purity and potency. Studies on similar mitochondrial peptides show detectable aggregation and oxidation beginning around day 30–35 even under ideal refrigeration. After 28 days, you're working with a compound of unknown potency, which makes any experimental results unreliable. For high-purity research peptides like those in our catalog, we recommend dating every reconstituted vial at the time of mixing and discarding any solution past the 28-day mark regardless of appearance.