Source comparison
MOTS-c Studied Mitochondrial Dysfunction Research: Comparison Across Protocols
Insulin Resistance Reversal (Human) HOMA-IR reduction, fasting insulin 10mg 3×/week SC for 4 weeks Acute: 48–72 hours; Peak: 10–14 days Effect size correlates with baseline dysfunction. Minimal response in healthy subjects Mitochondrial Bioenergetics (Rodent)
This comparison does not assign a generated winner or score.
- Insulin Resistance Reversal (Human)
- HOMA-IR reduction, fasting insulin
- 10mg 3×/week SC for 4 weeks
- Acute: 48–72 hours; Peak: 10–14 days
- Effect size correlates with baseline dysfunction. Minimal response in healthy subjects
- Mitochondrial Bioenergetics (Rodent)
- ATP production, respiratory control ratio
- 5mg/kg daily IP for 2–4 weeks
- Measurable at 72 hours; maximal at 14 days
- Rodent dosing doesn't translate directly to humans; human equivalent dose unclear
- Age-Related Muscle Function (Rodent)
- Grip strength, exercise endurance
- 5mg/kg 3×/week IP for 8 weeks
- Functional improvements at 4 weeks
- Mechanism may involve neuromotor adaptations, not purely mitochondrial
- Mitochondrial Stress Test (In Vitro)
- AMPK phosphorylation, GLUT4 translocation
- 10–50 μM in culture medium
- 30–60 minutes (phosphorylation); 2–4 hours (glucose uptake)
- In vitro concentrations far exceed physiological plasma levels achieved in vivo