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MOTS-c vs metformin

Metformin, a widely-used diabetes medication, also activates AMPK. This has led some to compare MOTS-c to metformin. Both compounds improve insulin sensitivity and have longevity research interest. However, they work through different mechanisms to activate AM

This comparison does not assign a generated winner or score.

  • Metformin, a widely-used diabetes medication, also activates AMPK. This has led some to compare MOTS-c to metformin.
  • Both compounds improve insulin sensitivity and have longevity research interest. However, they work through different mechanisms to activate AMPK. Metformin inhibits complex I of the mitochondrial electron transport chain. MOTS-c works through the folate-AICAR pathway.
  • Metformin has decades of human safety data and FDA approval. MOTS-c does not. For those already taking metformin, adding MOTS-c would introduce unknown interactions and duplicated mechanisms.
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