Source comparison
MOTS-c with Coffee Safety: Research Comparison
<100mg Within 2 hours <20% saturation Negligible. MOTS-c response preserved Safe for most protocols 150–200mg Within 3 hours 40–60% saturation Moderate. Glucose uptake may appear blunted by 15–25% Separate by 3+ hours 250–400mg 60–80% saturation Significant. M
This comparison does not assign a generated winner or score.
- <100mg
- Within 2 hours
- <20% saturation
- Negligible. MOTS-c response preserved
- Safe for most protocols
- 150–200mg
- Within 3 hours
- 40–60% saturation
- Moderate. Glucose uptake may appear blunted by 15–25%
- Separate by 3+ hours
- 250–400mg
- 60–80% saturation
- Significant. Mitochondrial biogenesis markers reduced by 30–40%
- Avoid overlap or delay caffeine 90+ min post-MOTS-c
- >400mg
- Same day
- 70–90% saturation
- Severe. MOTS-c-specific effects difficult to isolate
- Recommend 6+ hour separation or avoid same-day dosing