Source comparison
MT-1 vs MT-2 Stability
MT-2's cyclic structure gives it a meaningful stability advantage over MT-1. The lactam bridge physically impedes proteases from accessing and cleaving certain backbone positions. In cell culture and receptor assay conditions: MT-2 demonstrates good stability
This comparison does not assign a generated winner or score.
- MT-2's cyclic structure gives it a meaningful stability advantage over MT-1. The lactam bridge physically impedes proteases from accessing and cleaving certain backbone positions. In cell culture and receptor assay conditions:
- MT-2 demonstrates good stability over the timescales typical of cell-based assays (hours to days)
- MT-1, being linear, is somewhat more susceptible to proteolytic degradation, though its NDP-α-MSH modifications do provide substantially better stability than native α-MSH
- For long-duration incubation experiments, MT-2 is generally the more reliable choice purely from a stability standpoint.