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Oral Supplementation Versus Intravenous Administration

Most people obtain vitamin C through diet or oral supplements. However, the body tightly regulates plasma levels, and intestinal absorption drops sharply when high doses are taken orally. Because vitamin C is water‑soluble, excess amounts are excreted, limitin

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  • Most people obtain vitamin C through diet or oral supplements. However, the body tightly regulates plasma levels, and intestinal absorption drops sharply when high doses are taken orally.
  • Because vitamin C is water‑soluble, excess amounts are excreted, limiting the achievable blood concentration.
  • Intravenous (IV) therapy bypasses the gastrointestinal tract, allowing clinicians to deliver much higher doses directly into the bloodstream.
  • IV administration can produce plasma concentrations up to 100 times higher than oral supplementation.
  • These high levels are hypothesized to provide enhanced antioxidant and immune‑modulating effects.
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