Source comparison
Pe-22-28 vs Selank Amidate: Mechanism Comparison
Primary Structure Pentapeptide (5 amino acids), thymopoietin fragment (positions 32–36) Heptapeptide (7 amino acids), tuftsin analog with C-terminal amide modification Pe-22-28 is a natural sequence; Selank is synthetically optimized for stability Half-Life in
This comparison does not assign a generated winner or score.
- Primary Structure
- Pentapeptide (5 amino acids), thymopoietin fragment (positions 32–36)
- Heptapeptide (7 amino acids), tuftsin analog with C-terminal amide modification
- Pe-22-28 is a natural sequence; Selank is synthetically optimized for stability
- Half-Life in Plasma
- <10 minutes (unmodified termini susceptible to peptidase degradation)
- 2.5–4 hours (amidation blocks carboxypeptidase cleavage)
- Selank's extended half-life permits sustained CNS receptor engagement
- Primary Mechanism
- Thymic epithelial signaling → CD4+ T-cell differentiation, Treg expansion, IL-2/IL-7 upregulation
- Enkephalinase inhibition → GABA-ergic transmission enhancement, BDNF upregulation
- Non-overlapping pathways: immune restoration vs neuromodulation
- Target Tissue
- Thymus, peripheral lymphoid tissue, immature T-cells
- Central nervous system (amygdala, hippocampus, prefrontal cortex)
- Pe-22-28 does not cross BBB efficiently; Selank does
- Research Applications
- Autoimmune disease models, transplant rejection, immunosenescence, Treg cell studies
- Anxiety models, cognitive resilience, chronic stress, neuroprotection, learning/memory studies
- Choose based on whether the experimental endpoint is immune or CNS function
- Storage Requirements
- Lyophilised powder at −20°C; reconstitute immediately before use (degrades within hours at 4°C)
- Lyophilised powder at −20°C; reconstituted solution stable 7–10 days at 2–8°C due to amide protection
- Selank's stability advantage reduces experimental variability in multi-day protocols