Source comparison
Peptide Secretagogue Comparison — Mechanism and Practical Differences
CJC-1295 DAC GHRH analog; extends natural GH pulse duration 6–8 days 100–300mcg 2–3× weekly Stable IGF-1 elevation; convenient dosing Slower onset (48–72 hours to peak) Best foundational secretagogue for sustained protocols. Pairs well with short-acting ghreli
This comparison does not assign a generated winner or score.
- CJC-1295 DAC
- GHRH analog; extends natural GH pulse duration
- 6–8 days
- 100–300mcg
- 2–3× weekly
- Stable IGF-1 elevation; convenient dosing
- Slower onset (48–72 hours to peak)
- Best foundational secretagogue for sustained protocols. Pairs well with short-acting ghrelin mimetics
- Ipamorelin
- Ghrelin mimetic; triggers immediate GH release
- 2 hours
- 1–3× daily
- Minimal cortisol/prolactin spike; clean GH pulse
- Requires frequent dosing
- Safest ghrelin mimetic for long-term use. Ideal for stacking with CJC-1295
- Hexarelin
- Ghrelin mimetic; most potent GH secretagogue
- 70 minutes
- 100–200mcg
- 1× daily (max 6 weeks)
- Largest GH spike; fastest results
- Receptor desensitisation; cortisol elevation
- Use for short aggressive cycles only. Not sustainable long-term
- MK 677
- Non-peptide ghrelin mimetic; oral bioavailability
- 24 hours
- 10–25mg
- 1× daily (oral)
- No injections; steady-state GH elevation
- Constant (not pulsatile) GH; appetite increase
- Best for users who can't manage injection protocols. Less physiological than peptides
- Sermorelin
- GHRH analog; mimics natural GHRH
- 8–12 minutes
- 200–500mcg
- 1–2× daily
- Lowest side effect profile
- Very short half-life; multiple daily doses required
- Clinical favourite for age-related GH decline. Not practical for performance research