Source comparison
PT-141 Blood Work Labs: Cardiovascular vs Metabolic vs Hormonal Comparison
Cardiovascular Systolic BP, Diastolic BP, Resting HR, hs-CRP SBP 140 mmHg, sustained HR >90 bpm, hs-CRP >3.0 mg/L Baseline, 6 weeks, 12 weeks, then quarterly Blood pressure elevation is the most comm
This comparison does not assign a generated winner or score.
- Cardiovascular
- Systolic BP, Diastolic BP, Resting HR, hs-CRP
- SBP <130 mmHg, DBP <85 mmHg, HR 60–80 bpm, hs-CRP <1.0 mg/L
- SBP >140 mmHg, sustained HR >90 bpm, hs-CRP >3.0 mg/L
- Baseline, 6 weeks, 12 weeks, then quarterly
- Blood pressure elevation is the most common PT-141 adverse effect. Track it rigorously or risk missing hypertensive rebound
- Metabolic
- Fasting glucose, HbA1c, triglycerides, ALT, creatinine
- Glucose <100 mg/dL, HbA1c <5.7%, TG <150 mg/dL, ALT <40 U/L, creatinine <1.2 mg/dL
- Fasting glucose >110 mg/dL, triglycerides >200 mg/dL, creatinine increase >0.3 mg/dL from baseline
- Baseline, 12 weeks, then biannually
- Melanocortin signaling influences hepatic glucose output and lipid metabolism. These shift slowly but predictably with chronic use
- Hormonal
- Total testosterone, free testosterone, LH, FSH, estradiol (males), prolactin
- Total T 300–1000 ng/dL, LH 1.5–9.3 mIU/mL, FSH 1.4–18.1 mIU/mL
- LH suppression >20% from baseline, prolactin >25 ng/mL, unexplained testosterone drop >15%
- Baseline, 8 weeks, 16 weeks, then biannually
- PT-141 doesn't directly suppress HPG axis but does modulate GnRH pulsatility. Track gonadotropins separately from testosterone
- Inflammatory
- hs-CRP, ESR, homocysteine
- hs-CRP <1.0 mg/L, ESR <20 mm/hr, homocysteine <10 µmol/L
- hs-CRP >3.0 mg/L sustained, ESR >30 mm/hr, homocysteine >15 µmol/L
- Persistent elevation signals vascular stress that melanocortin activation may be compounding rather than resolving
- Complete Blood Count
- WBC, RBC, hemoglobin, hematocrit, platelets
- WBC 4.5–11 × 10⁹/L, Hgb 13.5–17.5 g/dL (males), Hct 38–50%, platelets 150–400 × 10⁹/L
- Hematocrit >52%, platelet count <100 × 10⁹/L, WBC >12 × 10⁹/L
- Baseline, 12 weeks, then annually
- Melanocortin receptors are expressed on immune cells. Abnormal counts suggest off-target immune activation
- Thyroid
- TSH, free T3, free T4
- TSH 0.4–4.0 mIU/L, free T3 2.3–4.2 pg/mL, free T4 0.8–1.8 ng/dL
- TSH >5.0 mIU/L, free T3 <2.0 pg/mL sustained
- Baseline, 16 weeks, then annually
- MC4R activation in hypothalamus may suppress TRH secretion over time. Catch subclinical hypothyroidism early