Source comparison
PT-141 + Kisspeptin: Peptide Stack Comparison
PT-141 Melanocortin agonist MC3R, MC4R (hypothalamus, brainstem) 45–60 4–6 hours None. Central only Activates arousal circuits; no LH/testosterone elevation Kisspeptin-10 GnRH secretagogue GPR54 (GnRH neurons) 30–60 LH peaks 60–90 min; T peaks 120–180 min Incr
This comparison does not assign a generated winner or score.
- PT-141
- Melanocortin agonist
- MC3R, MC4R (hypothalamus, brainstem)
- 45–60
- 4–6 hours
- None. Central only
- Activates arousal circuits; no LH/testosterone elevation
- Kisspeptin-10
- GnRH secretagogue
- GPR54 (GnRH neurons)
- 30–60
- LH peaks 60–90 min; T peaks 120–180 min
- Increases LH by 300–500%, T by 50–80%
- Restores HPG axis pulsatility; no central arousal effect
- Combined Stack
- Dual-axis
- Both central (MC4R) and hormonal (GPR54)
- 60–90 (alignment window)
- 4–6 hours (central), 3–5 hours (hormonal)
- PT-141: none; Kisspeptin: significant LH/T elevation
- Covers neurological and hormonal arousal deficits independently