Source comparison
PT-141 vs Viagra vs Cialis vs Trimix: Full Comparison
Each ED treatment works through a different mechanism. The comparison below helps determine which approach fits your situation. Brain (MC4R agonist) Vascular (PDE5 inhibitor) Vascular (direct injection) Route Subcutaneous injection Oral Penile injection 30-60
This comparison does not assign a generated winner or score.
- Each ED treatment works through a different mechanism. The comparison below helps determine which approach fits your situation.
- Brain (MC4R agonist)
- Vascular (PDE5 inhibitor)
- Vascular (direct injection)
- Route
- Subcutaneous injection
- Oral
- Penile injection
- 30-60 minutes
- 30-120 minutes
- 5-10 minutes
- 4-6 hours
- 24-36 hours
- 1-3 hours
- Addresses desire?
- Yes
- No
- Works for Viagra non-responders?
- Yes (34%)
- N/A
- Moderate
- Nausea rate
- 40%
- <3%
- <1%
- Food interaction
- None
- High-fat meals delay onset
- Cost per dose
- 15-40 USD
- 1-50 USD
- 10-30 USD
- FDA status (men)
- Off-label
- Approved
- Compounded
- PT-141's unique advantage is addressing desire, not just blood flow. Men who report "I can get an erection but I'm not interested" are ideal PT-141 candidates. Men with purely vascular ED and normal desire are better served by PDE5 inhibitors or trimix. For men in our peptides for men over 40 and peptides for men over 50 guides, PT-141 fills the desire gap that other treatments miss.