Source comparison
Quick Comparison Table
Parent molecule. Selank is derived from tuftsin (an IgG Fc fragment). Semax is derived from the ACTH(4-7) fragment. Sequence and molecular weight. Selank: Thr-Lys-Pro-Arg-Pro-Gly-Pro (751.9 Da). Semax: Met-Glu-His-Phe-Pro-Gly-Pro (813.9 Da). Primary mechanism.
This comparison does not assign a generated winner or score.
- Parent molecule. Selank is derived from tuftsin (an IgG Fc fragment). Semax is derived from the ACTH(4-7) fragment.
- Sequence and molecular weight. Selank: Thr-Lys-Pro-Arg-Pro-Gly-Pro (751.9 Da). Semax: Met-Glu-His-Phe-Pro-Gly-Pro (813.9 Da).
- Primary mechanism. Selank works through GABAergic modulation, enkephalin stabilization, and serotonin regulation. Semax works through BDNF and NGF upregulation via the CREB pathway, and dopaminergic sensitization.
- Primary effect. Selank is primarily anxiolytic and immunomodulatory. Semax is primarily a cognitive stimulant with neuroprotective properties.
- Subjective profile. Selank produces calm focus, reduced anxiety, and mood stability. Semax produces mental sharpness, increased alertness, and enhanced motivation.
- Russian approval. Selank was approved in Russia in 2009 for generalized anxiety disorder. Semax was approved for stroke, cognitive disorders, and optic nerve disease; it was added to Russia's List of Vital and Essential Drugs in 2011.
- Administration route and dosing. Both are administered intranasally (preferred) or subcutaneously. Standard dose for Selank: 200 to 400 mcg, 2 to 3 times daily, in 14-day courses with one-month breaks. Standard dose for Semax: 200 to 600 mcg, 1 to 2 times daily, in 10 to 30-day courses with 2 to 4-week breaks.
- Common side effects. Selank: nasal irritation and nasal dryness. Semax: nasal irritation, headache, and sleep disruption if dosed too late in the day.
- WADA status. Both are likely prohibited under the S0 blanket ban on unapproved substances.