Source comparison
Ranked Comparison: CJC-1295, Ipamorelin, MK-677, and Hexarelin
| Peptide | Mechanism | Peak GH Increase (vs Baseline) | Duration of Elevation | Selectivity | Cortisol/Prolactin Effect | Best Research Application ||—|—|—|—|—|—|| CJC-1295 with DAC | GHRH analogue. Extends natural pulsatile GH release | 200–300% | 6–8 days p
This comparison does not assign a generated winner or score.
- | Peptide | Mechanism | Peak GH Increase (vs Baseline) | Duration of Elevation | Selectivity | Cortisol/Prolactin Effect | Best Research Application ||—|—|—|—|—|—|| CJC-1295 with DAC | GHRH analogue. Extends natural pulsatile GH release | 200–300% | 6–8 days per injection | High (GHRH receptor-specific) | Minimal to none | Longitudinal recovery studies, circadian rhythm preservation, multi-day IGF-1 tracking || Ipamorelin | Ghrelin receptor agonist (GHRP) | 150–250% | 2–3 hours post-injection | Very high (growth hormone-selective) | Negligible | Acute GH response studies, body composition research without confounding cortisol variables || MK-677 (Ibutamoren) | Oral ghrelin mimetic | 60–90% sustained elevation | 14–21 days per dose cycle | Moderate (some appetite stimulation) | Minimal cortisol, appetite increase | Chronic IGF-1 studies, oral administration models, long-term anabolic signalling research || Hexarelin | Ghrelin receptor agonist (GHRP) | 400–600% | 90 minutes post-injectio
- Bottom Line: CJC-1295 with DAC delivers the longest-lasting elevation with preserved natural pulsatility, making it the top choice for multi-day recovery or IGF-1 research. Ipamorelin offers the cleanest acute GH spike without off-target hormonal noise. Ideal for body composition studies. MK-677 is the only oral option and sustains IGF-1 elevation for weeks, but appetite stimulation may confound metabolic studies. Hexarelin produces the highest single-dose GH spike but desensitises rapidly and elevates cortisol significantly. Use only in short-term, tightly controlled protocols.