Source comparison
Receptor Binding Profile Comparison Table
MC1R Melanocytes, macrophages, immune cells Pigmentation, anti-inflammatory signaling High (nanomolar Kd) Substantially reduced vs MT-2 MC2R Adrenal cortex (selective ACTH receptor) Cortisol production regulation Low-moderate Low MC3R Hypothalamus (arcuate nuc
This comparison does not assign a generated winner or score.
- MC1R
- Melanocytes, macrophages, immune cells
- Pigmentation, anti-inflammatory signaling
- High (nanomolar Kd)
- Substantially reduced vs MT-2
- MC2R
- Adrenal cortex (selective ACTH receptor)
- Cortisol production regulation
- Low-moderate
- Low
- MC3R
- Hypothalamus (arcuate nucleus), brainstem, gut
- Energy homeostasis, autonomic regulation, inflammation
- Moderate-high (retained)
- MC4R
- Hypothalamus (PVN, VMH), spinal cord, brainstem
- Appetite suppression, energy expenditure, autonomic outflow
- MC5R
- Exocrine glands (lacrimal, sebaceous), skeletal muscle
- Exocrine gland secretion, immune modulation
- Moderate