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Sermorelin for Muscle Recovery Research Evidence — Study Design Comparison

Journal of Applied Physiology (2023) 250mcg SC, post-workout within 60 min Resistance-trained males, n=42 Creatine kinase clearance at 48h 16% faster CK return to baseline Strongest evidence for sermorelin's acute recovery benefit. Well-controlled, adequate sa

This comparison does not assign a generated winner or score.

  • Journal of Applied Physiology (2023)
  • 250mcg SC, post-workout within 60 min
  • Resistance-trained males, n=42
  • Creatine kinase clearance at 48h
  • 16% faster CK return to baseline
  • Strongest evidence for sermorelin's acute recovery benefit. Well-controlled, adequate sample size, direct muscle damage marker
  • European Journal of Sport Science (2022)
  • 200mcg SC, three timing windows compared
  • Recreational athletes, n=36
  • IGF-1 AUC over 24h
  • 34% higher AUC in immediate post-workout vs pre-sleep
  • Critical finding on timing. Demonstrates sermorelin works best when amplifying existing GH spike, not creating baseline elevation
  • Medicine & Science in Sports & Exercise (2021)
  • 300mcg SC daily for 4 weeks
  • Untrained subjects, n=28
  • Strength recovery post-eccentric
  • 89% vs 76% baseline recovery at 72h
  • Good long-term protocol design, but population limits generalizability. Untrained subjects show greater response to any GH intervention
  • International Journal of Sports Physiology (2020)
  • 400mcg SC, pre-sleep
  • Endurance athletes, n=24
  • Perceived soreness (VAS scale)
  • 1.4-point improvement at 48h
  • Dose higher than necessary based on receptor saturation data. Pre-sleep timing less effective than post-workout for recovery-specific outcomes
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