Source comparison
Sermorelin Ipamorelin Protocol: Peptide Comparison
Sermorelin GHRH receptor agonist. Stimulates pituitary GH synthesis and release 200–500 mcg/day 10–20 minutes (plasma) Amplifies endogenous GH pulse amplitude Best for restoring pulsatile secretion; short half-life requires daily dosing Ipamorelin Ghrelin rece
This comparison does not assign a generated winner or score.
- Sermorelin
- GHRH receptor agonist. Stimulates pituitary GH synthesis and release
- 200–500 mcg/day
- 10–20 minutes (plasma)
- Amplifies endogenous GH pulse amplitude
- Best for restoring pulsatile secretion; short half-life requires daily dosing
- Ipamorelin
- Ghrelin receptor agonist. Blocks somatostatin inhibition of GH release
- 200–300 mcg/day
- ~2 hours
- Removes GH secretion brake; highly selective (no cortisol/prolactin spike)
- Cleanest secretagogue profile; synergistic when stacked with GHRH analogs
- CJC-1295 (DAC)
- Modified GHRH analog with albumin binding. Extends half-life to 6–8 days
- 2 mg once weekly
- 6–8 days
- Sustained GHRH activity without pulsatility
- Convenient dosing but loses natural pulse pattern; may cause blunted GH peaks
- GHRP-6
- First-gen ghrelin mimetic
- 100–200 mcg 2–3x/day
- 15–60 minutes
- Strong GH release but also elevates cortisol, prolactin, and appetite
- Effective but non-selective; hunger stimulation limits usability