Source comparison
Sermorelin vs. Other GH Secretagogues: Dosage Comparison
Sermorelin is one of several peptides that stimulate growth hormone release, but each works through a different receptor and requires different daily amounts. This table helps you understand where sermorelin fits and why your prescriber may recommend one over
This comparison does not assign a generated winner or score.
- Sermorelin is one of several peptides that stimulate growth hormone release, but each works through a different receptor and requires different daily amounts. This table helps you understand where sermorelin fits and why your prescriber may recommend one over another.
- Sermorelin
- 200-500 mcg
- GHRH receptor agonist
- 10-20 min
- Nightly before bed
- GH optimization, anti-aging
- CJC-1295 (no DAC)
- 100-300 mcg
- 30 min
- Short-acting GH pulse
- CJC-1295 (with DAC)
- 1,000-2,000 mcg
- 6-8 days
- 1-2x per week
- Sustained GH elevation
- Ipamorelin
- 200-300 mcg
- GHRP (ghrelin receptor)
- 2 hours
- 2-3x daily
- Clean GH release, fewer side effects
- Tesamorelin
- 2,000 mcg (2 mg)
- 26 min
- Daily
- Visceral fat reduction (FDA-approved)
- Key distinction: Sermorelin and CJC-1295 work on the same GHRH receptor. Stacking them at full doses is redundant. Combining sermorelin (GHRH pathway) with ipamorelin (GHRP pathway) activates two complementary mechanisms and produces a synergistic GH pulse larger than either peptide alone. This sermorelin + ipamorelin stack is the most prescribed GH protocol in clinical anti-aging practice. Use the CJC-1295/ipamorelin dosage calculator to model combined dosing.