Source comparison
Sermorelin vs. Tesamorelin | Comprehensive Comparison
Sermorelin and tesamorelin both are GHRH receptor agonists that work to stimulate the physiological production of GH. Produced by the pituitary in pulses, GH can reach about 10ng/ml in men and 14ng/ml in women, according to reference ranges [11]. Notably, GH c
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- Sermorelin and tesamorelin both are GHRH receptor agonists that work to stimulate the physiological production of GH. Produced by the pituitary in pulses, GH can reach about 10ng/ml in men and 14ng/ml in women, according to reference ranges [11].
- Notably, GH can be undetectable between pulses, even in healthy individuals. Thus, a single GH measurement is insufficient for providing information on a test subject’s total GH levels.
- Instead, scientists have to perform multiple GH tests over time to see how peptides like sermorelin or tesamorelin may affect the hormone’s synthesis.
- Then, the results can be plotted on a graph, forming a curve line that shows how GH levels rise and fall (Y axis) over time (X axis). The area under this graphed line, also known as the “area under the curve” (AUC), gives a complete picture of how much total GH is released during a given period.
- According to clinical data, sermorelin and tesamorelin both work by influencing total pulse area and AUC. On the other hand, they do not appear to increase pulse frequency or cause supraphysiological GH levels [7, 12].
- In addition, GH stimulates the production of an anabolic hormone called insulin-like growth factor-1 (IGF-1). Yet, IGF-1 does not follow the same pulsatile pattern and its levels depend on mean GH levels. This is why IGF-1 may also be used to boost growth hormone production.
- IGF-1 is further thought to mediate the majority of GH's anabolic effects, such as the potential for lean body mass increase.
- Here is the latest research on the effects of sermorelin and tesamorelin on GH and IGF-1 levels:
- Sermorelin, in a study involving 11 senior male participants receiving 2mg/daily injections over a span of 6 weeks, amplified overall GH levels (measured by AUC) by 82%. This surge in GH concentrations persisted for roughly two hours post-injection. Levels of IGF-1 remained unchanged with this once-daily regimen [12].
- Sermorelin at doses of 1mg and 2mg significantly increased both GH and IGF-1 in young and elderly male volunteers. Study authors reported that IGF-1 in the older men increased by 25% with the highest dose, reaching levels observed in the untreated younger individuals. Moreover, the increase in IGF-1 in elderly males persisted for two weeks after discontinuing sermorelin [13].
- Tesamorelin, administered in doses of 2mg/daily for two weeks, resulted in 69% higher total GH (AUC) in 13 middle-aged healthy males. IGF-1 levels increased by a substantial 122% [7].
- Tesamorelin was also administered to patients with type 2 diabetes at doses of up to 2mg/daily. Study authors reported a more modest 60% increase in IGF-1 after 12 weeks of therapy at this dosage [14].
- In brief, both tesamorelin and sermorelin effectively increase GH and IGF-1, albeit at different rates. We will now individually look at the purported benefits of both compounds.