SM-130686 vs MK-677 (Ibutamoren) — Peptide Comparison

SM-130686 vs MK-677 (Ibutamoren) — Peptide Comparison SM-130686 vs MK-677 (Ibutamoren) — compare dosing, benefits, safety profiles, side effects, and how they stack. See which peptide is right for you. At a Glance Dose Range SM-130686 5–20 mg MK-677 (Ibutamoren) 10–25 mg Frequency Multiple times daily Once daily Administration Oral capsule or powder Oral (capsule or liquid) Cycle Length 8-12 weeks Onset Speed Moderate (1-2 weeks) Evidence Level Moderate human trials (Phase 1-2) Efficacy Muscle and Strength Recovery and Performance Metabolic Health Muscle and body composition Recovery and athletic performance Sleep quality and metabolic health Technical Data Molecular Formula C22H24Cl2F3N3O3 Molecular Weight 506.3 g/mol (as HCl salt) Half-Life Not published in humans (preclinical only) Bioavailability 28% in rats (oral administration) CAS Number 259667-25-9 C27H36N4O5S 528.7 g/mol 4-6 hours (IGF-1 elevation persists ~24 hours) High oral bioavailability 159634-47-6 Protocols starting 10 mg 2-4 weeks initial Lower entry dose used in practice to limit water retention and appetite surge before titrating up. standard 25 mg Studied up to 1-2 years 25 mg once-daily oral is the dose used in the randomized trial in healthy older adults; increased GH/IGF-1 and fat-free mass [1]. Most-studied dose [2]. Applications Lean Mass Building in Trained Athletes SM-130686 targets GHS-R to stimulate GH release, which supports anabolic processes. Preclinical studies in rats showed significant increases in fat-free mass and body weight when combined with resistance training principles. Age-Related GH Decline As a GHS-R agonist, SM-130686 may help restore physiological GH secretion in adults experiencing age-related decline. The oral route is convenient for long-term administration. GH supports tissue repair, collagen synthesis, and recovery. May benefit individuals engaged in intensive resistance training or athletic performance work. Older Adults (60+) Seeking Body Composition Improvements MK-677 was designed for aging populations. It restores GH and IGF-1 to youthful levels, increases lean mass, and improves physical function in people over 60. A 2-year clinical trial showed a 1.1 kg gain in fat-free mass with only modest fat gain—ideal for maintaining strength in older age. Athletes and Fitness Enthusiasts Wanting Recovery Support Oral dosing makes MK-677 convenient for athletes. It enhances muscle protein synthesis, speeds recovery after intense training, and supports lean mass building without the hassle of injections. People with Chronic Wasting or Protein Deficiency Clinical trials show MK-677 helps treat protein-energy wasting in kidney disease and other conditions. It stimulates appetite (a feature in these populations) and preserves muscle tissue—making it useful for those losing mass despite good nutrition. Safety Profile Common Appetite stimulation Transient water retention Uncommon Joint or muscle aches Transient changes in blood glucose Serious Potential carpal tunnel syndrome Unknown effects on tumor growth Increased appetite Mild water retention or edema Elevated fasting glucose Joint or muscle pain Carpal tunnel syndrome or nerve compression symptoms Mild nausea or digestive upset Glucose dysregulation and diabetes risk Research Status FDA Status Research compound Safety Overview SM-130686 is a research compound that has never been tested in humans. All safety and efficacy data come from animal studies (primarily rats). No human clinical trials have been conducted. Use carries unknown risks. Potential side effects based on GH physiology and limited preclinical work. Contraindications xPregnancy or breastfeeding (no safety data) xActive cancer (GH stimulation may be contraindicated) xUncontrolled diabetes (may affect glucose metabolism) xSevere cardiovascular disease (GH effects on heart not fully characterized) MK-677 has been studied in hundreds of humans over 2+ years and is generally well tolerated. Most side effects are mild and manageable, especially with lower starting doses. The lack of injection requirement makes it safer than injectable GH in terms of infection risk and sterility concerns. However, it is not FDA approved and should be viewed as a research compound. xUncontrolled diabetes or severe glucose dysregulation xActive cancer or high cancer risk requiring caution with IGF-1 elevation xPregnancy or breastfeeding Decision Guide Choose SM-130686 if... Lean mass building (theoretical) Strength development (preclinical evidence) Body composition improvement (animal studies) Choose MK-677 (Ibutamoren) if... Building lean muscle mass and strength Improving overall body composition in aging adults Enhancing athletic recovery and performance Supporting metabolic health and fat loss