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Stability Comparison Studies

By exposing tesamorelin and native GHRH (or sermorelin) to biological fluids or DPP-IV enzyme preparations and measuring the time course of peptide degradation by HPLC or biological activity assay, researchers can directly quantify the stability advantage conf

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  • By exposing tesamorelin and native GHRH (or sermorelin) to biological fluids or DPP-IV enzyme preparations and measuring the time course of peptide degradation by HPLC or biological activity assay, researchers can directly quantify the stability advantage conferred by tesamorelin's N-terminal modification.
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Comparison

Receptor Pharmacology Comparisons

Comparing tesamorelin, sermorelin, and CJC-1295 in parallel receptor assays (binding affinity, cAMP induction, desensitization kinetics) produces the kind of comparative pharmacol…

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