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Systemic vs Local Delivery: Research Considerations for TB-500

A central scientific question in TB-500 administration research is whether systemic delivery — in which the compound is distributed throughout the body via the bloodstream — or local delivery — in which it is applied or delivered directly to the target tissue

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  • A central scientific question in TB-500 administration research is whether systemic delivery — in which the compound is distributed throughout the body via the bloodstream — or local delivery — in which it is applied or delivered directly to the target tissue — produces more effective or more targeted biological outcomes. This question is not unique to TB-500 but reflects a fundamental dilemma in the delivery of any bioactive compound whose effects are desired at specific tissue sites.
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