Source comparison
TB-4 vs TB-500: Research Comparison
Amino Acid Length 43 amino acids 17–23 amino acids (active fragment) TB-500's shorter sequence eliminates degradation-prone regions without sacrificing core actin-binding function Molecular Weight ~4,921 Da ~1,974 Da Lower molecular weight improves tissue pene
This comparison does not assign a generated winner or score.
- Amino Acid Length
- 43 amino acids
- 17–23 amino acids (active fragment)
- TB-500's shorter sequence eliminates degradation-prone regions without sacrificing core actin-binding function
- Molecular Weight
- ~4,921 Da
- ~1,974 Da
- Lower molecular weight improves tissue penetration and reduces immunogenicity risk in animal models
- Stability (Reconstituted, 2–8°C)
- 7–10 days at >90% potency
- 28+ days at >95% potency
- TB-500's extended stability window reduces protocol failures from peptide degradation mid-study
- Plasma Half-Life (Rodent Models)
- ~2.5 hours
- 6–8 hours
- Longer half-life allows less frequent dosing, improving animal welfare compliance and reducing handling variables
- Cost per Functional Unit
- $180–$320 per 5mg (vendor dependent)
- $45–$95 per 5mg (vendor dependent)
- TB-500 delivers 60–75% cost reduction per milligram without meaningful functional compromise in most assays
- Actin-Binding Activity
- 100% (reference standard)
- 85–95% (varies by assay)
- Functional difference is statistically insignificant in migration and wound healing models
- Secondary Pathway Activation (FAK, ILK)
- Full integrin signalling modulation
- Partial replication (~50–60% of TB-4 effect)
- Relevant only if your research question explicitly targets integrin-mediated pathways beyond actin dynamics
- Bottom Line
- Required for studies investigating TB-4's full signalling profile, including immune modulation and cardiac differentiation
- Optimal for wound healing, angiogenesis, and migration assays where actin sequestration is the primary mechanism
- Choose TB-500 unless your protocol specifically requires secondary signalling pathways that TB-500 does not fully replicate