Source comparison
TB-500 Dosage Cardiac Repair 2026: Protocol Comparison
Acute MI (murine) 10mg loading, 5mg maintenance Loading: 3× first week; Maintenance: 1× weekly 8 weeks 34% increase in coronary collateral density, 18% reduction in infarct size Gold standard for acute injury. Loading dose critical for inflammatory modulation
This comparison does not assign a generated winner or score.
- Acute MI (murine)
- 10mg loading, 5mg maintenance
- Loading: 3× first week; Maintenance: 1× weekly
- 8 weeks
- 34% increase in coronary collateral density, 18% reduction in infarct size
- Gold standard for acute injury. Loading dose critical for inflammatory modulation
- Chronic remodelling (porcine)
- 5mg weekly (no loading)
- 1× weekly
- 12 weeks
- 18% reduction in LV dilation, preserved EF at 42% vs 31% control
- Suitable for long-term structural prevention, not acute rescue
- Human-equivalent allometric
- 15–25mg weekly
- 2× weekly (divided dose)
- 12–16 weeks
- Extrapolated from BSA scaling and receptor saturation models
- Theoretical upper bound. Clinical data extremely limited
- Published human case reports
- 10–20mg weekly
- 2× weekly
- Variable (8–24 weeks)
- Anecdotal improvement in exercise tolerance, no controlled endpoint data
- Represents lower conservative range based on limited published human use