Source comparison
TB-500 Dosage for Cardiac Repair: Protocol Comparison
Rodent MI (Rutgers) 2–5mg 4 weeks Infarct size reduction 50% smaller infarct vs control Proof of mechanism. Timing-dependent protection Canine DCM (Veterinary) 5–7.5mg 8 weeks Exercise tolerance, NT-proBNP 34% improvement in 6-min walk distance Translational.
This comparison does not assign a generated winner or score.
- Rodent MI (Rutgers)
- 2–5mg
- 4 weeks
- Infarct size reduction
- 50% smaller infarct vs control
- Proof of mechanism. Timing-dependent protection
- Canine DCM (Veterinary)
- 5–7.5mg
- 8 weeks
- Exercise tolerance, NT-proBNP
- 34% improvement in 6-min walk distance
- Translational. Applicable to chronic heart failure models
- Porcine MI (JACC)
- 10mg
- 6 weeks
- Infarct expansion, ejection fraction
- 38% reduction in adverse remodeling
- Closest analog to human cardiac mass and physiology
- Equine cardiac stress
- 7.5mg
- 12 weeks
- Troponin levels, recovery time
- 28% faster return to baseline cardiac biomarkers
- Large animal data. Validates dosing in high-mass subjects