Source comparison
TB-500 Downstream Effects: Pathway Comparison
Angiogenesis VEGFR2 / HIF-1alpha 24–48 hours 14–21 days Capillary density, MMP-2 activity Self-sustaining once initiated. Doesn't require continuous dosing Immune Modulation Treg differentiation / IL-10 3–7 days 12–16 days CD4+CD25+FoxP3+ cell count, TNF-alpha
This comparison does not assign a generated winner or score.
- Angiogenesis
- VEGFR2 / HIF-1alpha
- 24–48 hours
- 14–21 days
- Capillary density, MMP-2 activity
- Self-sustaining once initiated. Doesn't require continuous dosing
- Immune Modulation
- Treg differentiation / IL-10
- 3–7 days
- 12–16 days
- CD4+CD25+FoxP3+ cell count, TNF-alpha levels
- Immune shifts outlast peptide presence. Indicates transcriptional changes
- Microglial M2 Polarisation
- Arginase-1 upregulation
- 48–72 hours
- 10–14 days
- iNOS/arginase-1 ratio, BDNF levels
- Neuroprotection is immune-mediated, not direct neuronal
- Extracellular Matrix Remodelling
- MMP-2 / TIMP balance
- 24–36 hours
- 7–10 days
- Collagen turnover markers
- Allows tissue remodelling but increases transient structural fragility