Source comparison
TB-500 Endurance Results Timeline Expect: Comparison
Days 1–7 VEGF upregulation, actin polymerization in endothelial cells No measurable performance change RT-PCR for VEGF mRNA, Western blot for protein Molecular signals present but no structural vascular change yet Days 8–21 Endothelial cell migration, early ca
This comparison does not assign a generated winner or score.
- Days 1–7
- VEGF upregulation, actin polymerization in endothelial cells
- No measurable performance change
- RT-PCR for VEGF mRNA, Western blot for protein
- Molecular signals present but no structural vascular change yet
- Days 8–21
- Endothelial cell migration, early capillary sprouting
- Minimal change in VO2 max (<5%)
- Immunohistochemistry (CD31 staining for capillaries)
- Angiogenic process initiated but immature vessels not yet perfused
- Days 22–42
- Capillary stabilization, pericyte recruitment, basement membrane formation
- VO2 max improves 8–13%, lactate clearance improves 10–15%
- Treadmill time-to-exhaustion, blood lactate curves
- Functional endurance gains emerge as new capillaries become perfused
- Days 43–84
- Peak capillary density reached, further gains plateau without exercise
- VO2 max plateaus, improvements maintain if training continues
- Capillary-to-fiber ratio histology, repeat VO2 max testing
- Maximum angiogenic effect achieved. Continued improvement requires ongoing mechanical stimulus