Source comparison
TB-500 for Achilles Tendonitis: Study Comparison
Equine superficial digital flexor tendon injury (Journal of Equine Veterinary Science) 10mg weekly × 6 weeks Collagen fiber alignment via histology 40% faster healing (6 weeks vs 10 weeks to load tolerance) VEGF upregulation, improved type I collagen ratio Gol
This comparison does not assign a generated winner or score.
- Equine superficial digital flexor tendon injury (Journal of Equine Veterinary Science)
- 10mg weekly × 6 weeks
- Collagen fiber alignment via histology
- 40% faster healing (6 weeks vs 10 weeks to load tolerance)
- VEGF upregulation, improved type I collagen ratio
- Gold standard model. Equine tendon structure closely mirrors human Achilles anatomy
- Rat Achilles tendon laceration model (Journal of Applied Physiology)
- 0.5mg/kg twice weekly × 4 weeks
- Tensile strength testing at 6 weeks
- 60% increase in ultimate tensile strength vs control
- Angiogenesis confirmed via CD31 immunostaining
- Demonstrated structural repair, not just symptomatic improvement
- In vitro human tenocyte culture (Journal of Cellular Biochemistry)
- 100ng/mL culture medium exposure
- Type I vs type III collagen mRNA expression
- 2.1× higher type I collagen gene expression
- Direct fibroblast modulation independent of angiogenesis
- Isolated cellular mechanism. Confirms TB-500 acts on collagen synthesis pathways directly