Source comparison
TB-500 for Joint Mobility Research: Model vs Reality Comparison
Rat meniscectomy OA model 10 mg/kg SC twice weekly × 8 weeks Cartilage erosion score (Mankin scale) 30% reduction vs control Demonstrates anti-inflammatory and matrix-protective effects. Not regeneration Rabbit ligament transection 5 mg/kg SC 3× weekly × 6 wee
This comparison does not assign a generated winner or score.
- Rat meniscectomy OA model
- 10 mg/kg SC twice weekly × 8 weeks
- Cartilage erosion score (Mankin scale)
- 30% reduction vs control
- Demonstrates anti-inflammatory and matrix-protective effects. Not regeneration
- Rabbit ligament transection
- 5 mg/kg SC 3× weekly × 6 weeks
- Ultimate tensile strength of healed tissue
- 25% increase vs control
- Improves tissue quality during repair. Doesn't prevent initial injury
- Mouse inflammatory arthritis (CIA)
- 2 mg/kg SC daily × 4 weeks
- Synovial inflammation score, joint swelling
- 40–50% reduction in inflammation markers
- Modulates immune response. Effect dependent on continued dosing
- In vitro chondrocyte culture
- 100–500 ng/mL continuous exposure
- Collagen type II gene expression, MMP-13 expression
- 35% increase in COL2A1, 40% decrease in MMP-13
- Cellular-level mechanism confirmed. Clinical translation uncertain