Source comparison
TB-500 for Tendon Healing: Comparison of Evidence Quality
Rodent RCTs Randomised, placebo-controlled Sprague-Dawley rats (n=40–60) 34% increased collagen, improved tensile strength at 14 days Dose scaling unclear; rat tendon biology differs from human Strong mechanistic evidence but not directly translatable Equine t
This comparison does not assign a generated winner or score.
- Rodent RCTs
- Randomised, placebo-controlled
- Sprague-Dawley rats (n=40–60)
- 34% increased collagen, improved tensile strength at 14 days
- Dose scaling unclear; rat tendon biology differs from human
- Strong mechanistic evidence but not directly translatable
- Equine trials
- Open-label, comparative
- Horses with SDFT injuries (n=12–24)
- Reduced lesion size, better fiber alignment at 6 months
- No blinding, subjective grading, small sample
- Supportive but methodologically weak
- Human cell culture
- In vitro dose-response
- Human tenocytes
- Enhanced proliferation and collagen synthesis at 10–100 ng/mL
- No in vivo validation, no injury model
- Confirms biological activity in human cells
- Human clinical trials
- None published
- N/A
- No Phase I/II/III data
- Evidence gap prevents clinical recommendation