Source comparison
TB-500 Post-Surgery Healing Research: Comparison Across Study Types
Preclinical. Rodent excisional wound Mice, full-thickness dorsal wound 750 mcg/kg subcutaneous daily × 10 days Time to complete re-epithelialization 34% faster (8.2 days vs 12.4 days) Species differences in healing kinetics; wound type not representative of su
This comparison does not assign a generated winner or score.
- Preclinical. Rodent excisional wound
- Mice, full-thickness dorsal wound
- 750 mcg/kg subcutaneous daily × 10 days
- Time to complete re-epithelialization
- 34% faster (8.2 days vs 12.4 days)
- Species differences in healing kinetics; wound type not representative of surgical incisions
- Strong mechanistic evidence but not directly applicable to human surgery
- Preclinical. Rodent incisional wound
- Rats, midline laparotomy
- 6 mg/kg subcutaneous every 48 hours × 14 days
- Breaking strength at incision site
- 28% higher tensile strength at day 14
- Rodent fascial healing differs from human; no infection or complication modeling
- Best available model for clean surgical wounds but dosing not translatable
- Veterinary. Equine surgical wound
- Horses, distal limb wounds post-debridement
- 2 mg subcutaneous twice weekly × 4 weeks
- Time to complete epithelialization
- 12 days faster (34 days vs 46 days)
- Equine wounds heal by second intention; different from primary closure in humans
- Clinically relevant large animal data but wound type limits generalizability
- Human case report. Orthopedic surgery
- Single patient, ACL reconstruction with delayed healing
- 2 mg subcutaneous twice weekly × 6 weeks
- Subjective wound assessment and pain scores
- Not quantified; author reported 'improved healing'
- No control group, no objective outcome measures, publication bias
- Anecdotal only; insufficient to guide clinical practice
- Human pilot study. Chronic wound adjunct
- 12 patients with non-healing surgical wounds
- 750 mcg subcutaneous 3× weekly × 8 weeks
- Wound area reduction
- 37% mean reduction (not statistically powered for significance)
- Open-label, no placebo arm, heterogeneous wound types
- Suggests signal worth investigating but not evidence of efficacy