Source comparison
TB 500 Same as TB-500: Naming Comparison and Supplier Variations
The peptide designation 'TB 500' versus 'TB-500' has no regulatory distinction. No international peptide nomenclature body or pharmacopeia standard differentiates the two. Both refer to the same 43-amino-acid synthetic peptide derived from Thymosin Beta-4. The
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- The peptide designation 'TB 500' versus 'TB-500' has no regulatory distinction. No international peptide nomenclature body or pharmacopeia standard differentiates the two. Both refer to the same 43-amino-acid synthetic peptide derived from Thymosin Beta-4. The variation appears because different peptide manufacturers, research institutions, and academic journals adopted inconsistent cataloging conventions during early peptide commercialization in the 1980s and 1990s.
- TB 500
- Early peptide supplier catalogs (1980s–1990s)
- Commercial peptide suppliers, procurement databases
- Thymosin Beta-4, 1-43 amino acid sequence, 4963 Da
- No structural difference. Purely stylistic variation
- TB-500
- Academic research publications and institutional protocols
- Peer-reviewed journals, research protocols, grant applications
- Identical compound. Hyphen added for catalog organization
- Thymosin Beta-4 (Tβ4)
- Native protein nomenclature from biochemical isolation studies
- Fundamental biology research, textbook references
- Native and synthetic versions both 43 amino acids, 4963 Da
- Refers to both native and synthetic forms depending on context
- Suppliers often list both names in product descriptions to capture search variations. 'TB 500 (TB-500)' appears frequently on peptide vendor sites. This dual listing confirms they are the same product. What matters when comparing suppliers is not the hyphen but the peptide specifications: purity percentage (aim for ≥98%), molecular weight confirmation via mass spectrometry, sequence verification, and endotoxin testing results. Real Peptides publishes full CoA data for TB 500 Thymosin Beta 4 on every product page, including HPLC chromatograms and MS spectra. Transparency that generic peptide resellers rarely provide.
- Another common naming confusion involves 'TB4-Frag' or 'Thymosin Beta-4 Fragment'. These typically refer to shorter peptide sequences derived from specific regions of the full Thymosin Beta-4 protein. For example, the 17-23 amino acid fragment has been studied separately for its specific receptor binding properties. These are NOT the same as TB 500 or TB-500, which encompass the full 1-43 sequence. Always verify the amino acid range in the product specification sheet.
- One supplier variation worth noting: some vendors offer 'acetate salt' versus 'free base' forms. The acetate salt version includes acetic acid counter-ions that stabilize the peptide in lyophilized form and improve solubility during reconstitution. The free base version contains no counter-ions. Both deliver the same active peptide once dissolved, but acetate salts typically reconstitute faster and remain stable longer at 2–8°C. Real Peptides uses acetate salt formulations across research-grade peptides for maximum stability during shipping and storage.