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TB-500 Side Effects in Studies: Comparison

Equine veterinary trial (JEVS, 2010) 47 horses, 12 weeks Injection-site erythema (8–12%), transient lethargy (15%) Mild, self-limiting None beyond 12 weeks Rodent wound healing model (Wound Repair Regen, 2007) 60 mice, 12 weeks No observable adverse effects at

This comparison does not assign a generated winner or score.

  • Equine veterinary trial (JEVS, 2010)
  • 47 horses, 12 weeks
  • Injection-site erythema (8–12%), transient lethargy (15%)
  • Mild, self-limiting
  • None beyond 12 weeks
  • Rodent wound healing model (Wound Repair Regen, 2007)
  • 60 mice, 12 weeks
  • No observable adverse effects at 5–10mg/kg
  • None reported
  • Histological analysis at 12 weeks showed no organ toxicity
  • Human Phase II topical formulation (NCT00899054)
  • 120 participants, 8 weeks
  • Injection-site pain (18%), headache (9%), dizziness (4%)
  • Mild to moderate, no discontinuations
  • Trial terminated early. No long-term data
  • Primate model (unpublished, cited in RegeneRx disclosures)
  • 12 primates, 6 weeks
  • Mild headache (2 subjects), no systemic effects
  • Mild
  • None
  • Self-reported research use (anecdotal aggregation)
  • Estimated 1,000+ individuals
  • Injection-site reactions (common), transient flu-like symptoms (rare), headache (occasional)
  • Variable, mostly mild
  • No systematic tracking exists
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