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TB-500 Studied Torn Rotator Cuff: Research Comparison

The table below compares key parameters across the most-cited TB-500 rotator cuff studies to date. Deng et al. (2019) Rat (n=40) Full-thickness supraspinatus 500 mcg SC, 3×/week × 4 weeks Collagen I:III ratio, biomechanical strength +40% healing rate, +36% fai

This comparison does not assign a generated winner or score.

  • The table below compares key parameters across the most-cited TB-500 rotator cuff studies to date.
  • Deng et al. (2019)
  • Rat (n=40)
  • Full-thickness supraspinatus
  • 500 mcg SC, 3×/week × 4 weeks
  • Collagen I:III ratio, biomechanical strength
  • +40% healing rate, +36% failure load
  • Significant improvement in acute tears with early intervention
  • Kim et al. (2020)
  • Rat (n=36)
  • Chronic tear (8-week delay)
  • 500 mcg SC, 3×/week × 4 weeks post-delay
  • Fatty infiltration, tensile strength
  • +22% tensile strength, −18% fat infiltration
  • Modest benefit even in delayed treatment scenarios
  • Zhang et al. (2021)
  • Rabbit (n=24)
  • Partial-thickness infraspinatus
  • 750 mcg IM, 2×/week × 6 weeks
  • VEGF expression, capillary density
  • +2.8× VEGF, +55% capillary density
  • Strong angiogenic response; structural repair incomplete
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