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Tesamorelin Growth Hormone Results Timeline: Full Comparison

Week 1–2 +20–35% 0–1% (not significant) None visible; possible mild fluid retention Fasting GH transiently elevated Receptor priming phase—no morphological changes expected Week 4–8 +30–50% sustained 2–5% Waist circumference may decrease 1–2cm HOMA-IR begins d

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  • Week 1–2
  • +20–35%
  • 0–1% (not significant)
  • None visible; possible mild fluid retention
  • Fasting GH transiently elevated
  • Receptor priming phase—no morphological changes expected
  • Week 4–8
  • +30–50% sustained
  • 2–5%
  • Waist circumference may decrease 1–2cm
  • HOMA-IR begins declining in responders
  • Early enzymatic upregulation; lipolysis initiating
  • Week 12
  • +40–60%
  • 8–12%
  • Noticeable abdominal circumference reduction
  • Fasting insulin ↓ 10–15%, triglycerides ↓ 8–12%
  • Critical decision point—<5% VAT loss suggests non-response
  • Week 20–26
  • +45–65%
  • 12–18% (peak)
  • Visible midsection reduction; belt size down 1–2 notches
  • HbA1c may improve 0.2–0.4% in pre-diabetic range
  • Plateau phase—maximum VAT reduction achieved
  • Week 52 (continued dosing)
  • +40–55%
  • 10–16% maintained
  • Sustained midsection reduction
  • Metabolic markers stable
  • Maintenance phase—effects preserved with daily dosing
  • 12 weeks post-discontinuation
  • Returns to baseline
  • 40–60% regained
  • VAT accumulation resumes
  • Insulin resistance begins returning
  • Rebound effect—benefits not permanent without continued use
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