Source comparison
Tesamorelin + Ipamorelin Blend: Dosing and Timing Comparison
Standard Dose 1–2mg daily 200–300mcg nightly 1mg tes + 250mcg ipa Combination preserves pulsatile GH while sustaining baseline elevation Injection Timing Morning fasting 30 min pre-sleep Evening fasting (60–90 min post-meal) Aligns with natural nocturnal GH pe
This comparison does not assign a generated winner or score.
- Standard Dose
- 1–2mg daily
- 200–300mcg nightly
- 1mg tes + 250mcg ipa
- Combination preserves pulsatile GH while sustaining baseline elevation
- Injection Timing
- Morning fasting
- 30 min pre-sleep
- Evening fasting (60–90 min post-meal)
- Aligns with natural nocturnal GH peak and maximizes lipolysis during fasting
- Dosing Frequency
- Daily
- 5–6 nights/week
- 5 nights/week (weekday protocol)
- Prevents receptor downregulation. 2-day breaks maintain sensitivity
- Expected VAT Reduction (16 weeks)
- 10–15%
- 3–6% (indirect via lipolysis)
- 8–12%
- Tesamorelin drives VAT loss; ipamorelin sustains endogenous pulse amplitude
- Lean Mass Impact
- +1–2kg
- Neutral to +0.5kg
- +1–1.5kg
- GH's anabolic effect on muscle protein synthesis requires sustained elevation
- Professional Assessment
- Gold standard for visceral fat but may suppress natural GH pulse over time
- Maintains physiological GH rhythm but insufficient alone for significant VAT loss
- Optimal balance. Tesamorelin targets VAT directly while ipamorelin prevents adaptive suppression