Source comparison
Tesamorelin vs Sermorelin
Sermorelin is the first 29 amino acids of natural GHRH. It was FDA-approved for pediatric growth hormone deficiency (brand name Geref) but was discontinued in 2008 for commercial reasons, not safety concerns. Structure Modified GHRH (1-44) with hexenoic acid G
This comparison does not assign a generated winner or score.
- Sermorelin is the first 29 amino acids of natural GHRH. It was FDA-approved for pediatric growth hormone deficiency (brand name Geref) but was discontinued in 2008 for commercial reasons, not safety concerns.
- Structure
- Modified GHRH (1-44) with hexenoic acid
- GHRH (1-29)
- ~11 minutes
- FDA status
- Approved (Egrifta)
- Discontinued (Geref)
- Fat loss data
- Phase 3 trial data
- No fat-specific trial data
- 200-500 mcg/day
- Cost
- Sermorelin's shorter half-life means it produces a weaker GH pulse per injection. The hexenoic acid modification on tesamorelin is specifically what gives it the pharmacokinetic edge. For fat loss, tesamorelin is the stronger choice when budget allows. For general anti-aging and GH optimization on a budget, sermorelin remains popular in clinical practice.
- For dosing details on other GH secretagogues, see our guides on hexarelin dosage and MOTS-c peptide dosage.