Source comparison
Thymosin Alpha-1 Half-Life: Peptide Comparison
Thymosin Alpha-1 2–3 hours Twice daily (every 8–12 hours) Proteolytic degradation in plasma Shortest half-life among immune peptides. Twice-daily dosing is non-negotiable for sustained immune signaling BPC-157 4–6 hours Once daily or divided twice daily Enzyma
This comparison does not assign a generated winner or score.
- Thymosin Alpha-1
- 2–3 hours
- Twice daily (every 8–12 hours)
- Proteolytic degradation in plasma
- Shortest half-life among immune peptides. Twice-daily dosing is non-negotiable for sustained immune signaling
- BPC-157
- 4–6 hours
- Once daily or divided twice daily
- Enzymatic cleavage, renal filtration
- Moderate half-life allows once-daily dosing in most protocols, though some practitioners prefer split dosing for acute injury
- TB-500 (Thymosin Beta-4)
- 24–36 hours
- Twice weekly
- Slow enzymatic degradation, tissue binding
- Long half-life and tissue depot effect make weekly dosing sufficient for structural repair protocols
- Selank
- 20–30 minutes
- 2–3 times daily (nasal spray)
- Rapid enzymatic cleavage in nasal mucosa
- Extremely short half-life requires frequent dosing. Intranasal route bypasses first-pass but doesn't extend duration
- Semax
- 60–90 minutes
- Proteolytic degradation in CNS
- Slightly longer than Selank but still requires multiple daily doses for cognitive support protocols
- Thymosin alpha-1's 2–3 hour half-life sits between ultra-short peptides like Selank (which require 3+ daily doses) and long-acting compounds like TB-500 (which sustain levels for days). The twice-daily schedule represents the minimum frequency needed to maintain immune activation without requiring impractical dosing intervals.