Source comparison
Thymosin Beta 4 vs TB-500: Research Application Comparison
Before selecting a peptide for your study protocol, understanding how the structural and functional differences translate into practical research outcomes is essential. The table below compares key characteristics. Amino Acid Length 43 amino acids 7–17 amino a
This comparison does not assign a generated winner or score.
- Before selecting a peptide for your study protocol, understanding how the structural and functional differences translate into practical research outcomes is essential. The table below compares key characteristics.
- Amino Acid Length
- 43 amino acids
- 7–17 amino acids (varies by vendor)
- Full protein contains regulatory sequences absent in fragment
- Molecular Weight
- ~4,963 Daltons
- ~889 Daltons
- Smaller size may improve tissue penetration but reduces binding sites
- Actin Binding Affinity
- High (1:1 stoichiometry)
- Low to moderate
- TB-500 does not replicate actin-sequestering function fully
- Half-Life (Estimated)
- 18–24 hours (human, SC)
- 24–36 hours (estimated)
- TB-500 may have marginally longer stability in vivo
- Primary Research Use
- Wound healing, myocardial repair, hair follicle activation
- Angiogenesis, soft tissue repair, inflammation modulation
- Choose based on mechanism: actin regulation = Tβ4; angiogenesis focus = TB-500
- Cost per mg (2026)
- $85–$120 per 5mg vial
- $45–$75 per 5mg vial
- TB-500 is typically 40–50% less expensive
- The cost differential matters for large-scale studies. A 12-week rodent trial dosing 2mg per animal twice weekly would require approximately 48mg of peptide per subject. At that scale, the $40/vial savings with TB-500 adds up quickly. But cost savings mean nothing if the mechanism you're studying requires the full protein's actin-binding capacity.