Source comparison
Tolerance to Melanotan-2 Cycling: Protocol Comparison
Daily Loading 250–500mcg/day 14–21 days 4–6 weeks Maximum downregulation by day 21; fastest initial response Rapid tan acquisition before travel or event Every-Other-Day Maintenance 250mcg every 48h 3–4 weeks Moderate downregulation; sustained effect with slow
This comparison does not assign a generated winner or score.
- Daily Loading
- 250–500mcg/day
- 14–21 days
- 4–6 weeks
- Maximum downregulation by day 21; fastest initial response
- Rapid tan acquisition before travel or event
- Every-Other-Day Maintenance
- 250mcg every 48h
- 3–4 weeks
- Moderate downregulation; sustained effect with slower tolerance buildup
- Maintaining base tan across summer months
- Microdosing
- 50–100mcg every 72–96h
- Ongoing (no fixed cycle)
- Periodic 3–4 week breaks every 12 weeks
- Minimal downregulation; steady low-level receptor occupancy
- Long-term pigmentation maintenance post-loading
- Pulsed High-Dose
- 500mcg–1mg 2×/week
- 3 weeks
- 6–8 weeks
- High receptor saturation spikes; accelerated desensitisation
- Research protocols only; not recommended for cosmetic use