Source comparison
Tolerance to Sermorelin Cycling: Comparison
Continuous Daily Dosing 100–300mcg daily without breaks 40–50% of baseline pulse amplitude Requires 4–6 weeks complete washout Fastest route to tolerance. GH response declines predictably after week 8 regardless of dose 5-Days-On / 2-Days-Off (Micro-Cycle) 5 c
This comparison does not assign a generated winner or score.
- Continuous Daily Dosing
- 100–300mcg daily without breaks
- 40–50% of baseline pulse amplitude
- Requires 4–6 weeks complete washout
- Fastest route to tolerance. GH response declines predictably after week 8 regardless of dose
- 5-Days-On / 2-Days-Off (Micro-Cycle)
- 5 consecutive days, 2 days off weekly
- 75–80% of baseline pulse amplitude
- Partial recovery within 48–72 hours
- Slows tolerance curve significantly but doesn't prevent it. Still requires macro-cycle breaks
- 8-Weeks-On / 4-Weeks-Off (Macro-Cycle)
- Continuous use for 8 weeks, then complete 4-week break
- Returns to ~90% baseline after washout
- 3–4 weeks for full receptor resensitisation
- Most sustainable long-term protocol. Preserves receptor density across multiple cycles
- Dose Escalation Strategy
- Increase dose when response declines
- 60–70% of baseline (temporary)
- Accelerates next tolerance phase
- Works short-term but compounds receptor downregulation. Not recommended