Source comparison
Tolerance to Tesamorelin + Ipamorelin Blend: Peptide Stability vs Receptor Stability
Receptor Target GHRH receptor (Gs-coupled GPCR) Ghrelin receptor GHSR1a (Gq-coupled GPCR) Dual-pathway activation amplifies GH pulse. Cycling prevents downregulation of both Receptor Downregulation Timeline 40–55% density loss by week 8 with continuous use 20–
This comparison does not assign a generated winner or score.
- Receptor Target
- GHRH receptor (Gs-coupled GPCR)
- Ghrelin receptor GHSR1a (Gq-coupled GPCR)
- Dual-pathway activation amplifies GH pulse. Cycling prevents downregulation of both
- Receptor Downregulation Timeline
- 40–55% density loss by week 8 with continuous use
- 20–30% signal efficiency loss by week 10–12
- 5/2 microcycle + 7-day macrocycle maintains 80–90% receptor function at week 12
- Half-Life in Reconstituted Form
- 7–10 days at 2–8°C in bacteriostatic water
- 5–7 days at 2–8°C in bacteriostatic water
- Storage stability is NOT the tolerance variable. Receptor kinetics are
- Washout Period for Receptor Recovery
- 4–6 days for partial recovery; 7–10 days for full upregulation
- 3–5 days for signal transduction normalisation
- Full 7–10 day break every 8–12 weeks restores baseline sensitivity
- Professional Assessment
- Cycling isn't optional. It's mechanistically required to prevent ligand-induced receptor internalisation and degradation
- Neither peptide 'stops working'. Receptors adapt. Cycling reverses that adaptation at the transcriptional level
- Tolerance is receptor-level, not peptide-level; cycling protocols should start on day one, not after response drops